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apalutamide will decrease the level or impact of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medication which can be CYP3A4 substrates may end up in decrease publicity to those prescription drugs.

fosamprenavir will raise the stage or impact of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

enasidenib will minimize the level or effect of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Enasidenib (a weak CYP3A4 inducer) may minimize systemic publicity of CYP3A4 substrates. Check and regulate dose of substrate as clinically indicated.

Thyroid hormones may possibly improve the threat of coronary insufficiency when sympathomimetic agents are administered to individuals with read more coronary artery condition.

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Though a thienodiazepine, etizolam is clinically viewed as a benzodiazepine because of its method of motion by means of the benzodiazepine receptor and directly concentrating on GABAA allosteric modulator receptors.[five]

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Contraindicated. Increased hazard of ergotism leading to cerebral ischemia and/or ischemia of the extremitiesMinor (one)itraconazole raises amounts of caffeine by reducing metabolism. Minor/Significance Unfamiliar.

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Coadministration of pexidartinib (a CYP3A4 inducer) with delicate CYP3A substrates may perhaps result in major therapeutic failures. If concomitant use is unavoidable, improve the CYP3A substrate dosage in accordance with authorised product labeling.

cobicistat will raise the stage or result of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.